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Have You Heard? Volume 1, Issue 12 -- Published: Friday, Oct 31, 1997 -- Last Updated: Monday, Mar 11, 2002
Researchers at Yale University compared lower and higher doses of buprenorphine with lower and higher doses of methadone for their respective ability to promote abstinence from opiates. The results, published in Archives of General Psychiatry (54: 713-719), demonstrated that buprenorphine was no more likely than methadone to be associated with cocaine free urines in a double blind sample of 116. Higher doses of each drug were associated with lower likelihood of opiates in the urine. Seventy psychiatrists in training in a Canadian study (Canadian Jl Psychiatry (42) 7: 758-763) were followed prospectively to determine testing variables associated with later sexual misconduct. Two who later were disciplined for repeated sexual misconduct had displayed an MMPI profile known as 4/9, with elevations of the psychopathic deviate and hypomania scales, and elevations of the K validity scale as well. Schizophrenia Research (26: 18 1-190) reported findings from a study of a group of hallucinating patients. The Australian researchers found a group of 31 patients who were more likely to be violent when their hallucinations were more bossy, malicious, and critical in tone and when their delusions were persecutory as opposed to grandiose, and to be angered or agitated by their hallucinations . . . A study of the MMPI-2 in child custody litigants (Psychological Assessment (9) 3: 205-2 11) found no differences between mothers, fathers, or stepparents. The findings of 508 participants could not explain the ultimate meaning of the test defensive patterns seen in the scores...Psychiatric Services ((48)10: 1297-1306) featured a comparison study of two assertive community treatment teams vs. usual method of care for those with serious and persistent mental illness. Not surprisingly, the assertive community treatment approaches were associated with a greater retention of patients in treatment, 68 to 43% . . . Mazindol, which like cocaine blocks dopamine and norepinephrine reuptake in the brain, was examined for its impact on promoting cocaine abstinence. Only modest results were demonstrated at doses up to 8 mg in a sample of 17 cocaine dependent methadone maintained patients, in a study reported in Substance Abuse ((18) 3:125-131).
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